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WhatsApp: +86 18221755073MLL, a mammalian trithorax-group gene, functions as a
Branchial arch abnormalities in Mll knockout embryos. Gross views and TUNEL staining of control and Mll−/− E10.5 embryos.(A) Wild-type embryo (oblique view), demonstrating normal structures of the first branchial arch, maxillary prominence (MX), the mandibular component (MA), and associated trigeminal ganglia (arrowhead).(B) Mll−/− …
WhatsApp: +86 18221755073Molecular Basis of the Mixed Lineage Leukemia-Menin …
Menin, which directly binds MLL, has been identified as an essential oncogenic co-factor required for the leukemogenic activity of MLL fusion proteins. Here, we characterize the …
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Huret, JL, Brizard, A, Slater, R, et al. Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytogenetic analyses of 48 patients -- updated published cases and 16 new ...
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Mixed-lineage-leukemia is an aggressive leukemia that predominantly occurs in pediatric patients and is characterized by the expression of fusion genes involving the histone …
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Blocking the MLL-menin interaction by the expression of a dominant negative inhibitor composed of amino terminal MLL sequences down-regulates Meis1 expression and inhibits cell proliferation, suggesting that targeting this interaction may be an effective therapeutic strategy for leukemias with MLL rearrangements.
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MLL, the human homolog of Drosophila trithorax, maintains Hox gene expression in mammalian embryos and is rearranged in human leukemias resulting in Hox gene deregulation. How MLL or MLL fusion proteins regulate gene expression remains obscure. We show that MLL regulates target Hox gene expression t …
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Abnormalities of the MLL gene were not detected in any of the 15 cases with a deletion or inversion of the chromosomes 11q23 region. The presence of an MLL rearrangement was significantly associated with age less than 1 year (P < .001), leukocyte count –>50 x 10(9)/L (P = .003), and the absence of leukemic cell CD10 expression (P < …
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A second type of MLL gene alteration is the partial tandem duplication (PTD), which occurs in acute myeloid leukemia (AML). We found four AML cell lines with an MLL PTD; one acute lymphoblastic ...
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